High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients

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High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients. / El Gammal, Alexander Tarek; Melling, Nathaniel; Reeh, Matthias; Gebauer, Florian; Mann, Oliver; Perez, Daniel; Bockhorn, Maximillian; Bachmann, Kai; Izbicki, Jakob Robert; Grupp, Katharina.

In: EXP MOL PATHOL, Vol. 107, 04.2019, p. 51-56.

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@article{766f1ef85cb54dbe84ba2d886ff5b997,
title = "High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients",
abstract = "Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in esophageal cancers remains unclear. Immunohistochemical RAI3 staining was analyzed on tissue microarrays containing 359 esophageal adenocarcinomas (EAC) and 254 esophageal squamous cell carcinomas (ESCC). RAI3 immunostaining was typically absent or weakly detectable in the membranes in benign esophageal tissues. RAI3 staining was higher in malignant than in benign esophagus epithelium. High-levels of RAI3 staining were found in 79.2% of interpretable EACs and 55.9% of ESCCs. In EACs, strong RAI3 staining was associated with advanced pathological tumor stage (p < .0001), high UICC stage (p < .0001), high tumor grade (p = .0133), and positive lymph nodal status (p = .0002). Additionally, high RAI3 staining predicted shortened overall survival of EAC and ESCC patients (p = .0298 and p = .0227). RAI3 overexpression is associated with poor prognosis in esophageal cancers. We propose that RAI3 overexpression might play a biologically relevant role of RAI3 in esophageal cancers.",
keywords = "Adenocarcinoma/mortality, Adult, Aged, Biomarkers, Tumor/analysis, Esophageal Neoplasms/mortality, Esophageal Squamous Cell Carcinoma/mortality, Female, Humans, Male, Middle Aged, Prognosis, Receptors, G-Protein-Coupled/biosynthesis",
author = "{El Gammal}, {Alexander Tarek} and Nathaniel Melling and Matthias Reeh and Florian Gebauer and Oliver Mann and Daniel Perez and Maximillian Bockhorn and Kai Bachmann and Izbicki, {Jakob Robert} and Katharina Grupp",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = apr,
doi = "10.1016/j.yexmp.2019.01.013",
language = "English",
volume = "107",
pages = "51--56",
journal = "EXP MOL PATHOL",
issn = "0014-4800",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients

AU - El Gammal, Alexander Tarek

AU - Melling, Nathaniel

AU - Reeh, Matthias

AU - Gebauer, Florian

AU - Mann, Oliver

AU - Perez, Daniel

AU - Bockhorn, Maximillian

AU - Bachmann, Kai

AU - Izbicki, Jakob Robert

AU - Grupp, Katharina

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/4

Y1 - 2019/4

N2 - Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in esophageal cancers remains unclear. Immunohistochemical RAI3 staining was analyzed on tissue microarrays containing 359 esophageal adenocarcinomas (EAC) and 254 esophageal squamous cell carcinomas (ESCC). RAI3 immunostaining was typically absent or weakly detectable in the membranes in benign esophageal tissues. RAI3 staining was higher in malignant than in benign esophagus epithelium. High-levels of RAI3 staining were found in 79.2% of interpretable EACs and 55.9% of ESCCs. In EACs, strong RAI3 staining was associated with advanced pathological tumor stage (p < .0001), high UICC stage (p < .0001), high tumor grade (p = .0133), and positive lymph nodal status (p = .0002). Additionally, high RAI3 staining predicted shortened overall survival of EAC and ESCC patients (p = .0298 and p = .0227). RAI3 overexpression is associated with poor prognosis in esophageal cancers. We propose that RAI3 overexpression might play a biologically relevant role of RAI3 in esophageal cancers.

AB - Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in esophageal cancers remains unclear. Immunohistochemical RAI3 staining was analyzed on tissue microarrays containing 359 esophageal adenocarcinomas (EAC) and 254 esophageal squamous cell carcinomas (ESCC). RAI3 immunostaining was typically absent or weakly detectable in the membranes in benign esophageal tissues. RAI3 staining was higher in malignant than in benign esophagus epithelium. High-levels of RAI3 staining were found in 79.2% of interpretable EACs and 55.9% of ESCCs. In EACs, strong RAI3 staining was associated with advanced pathological tumor stage (p < .0001), high UICC stage (p < .0001), high tumor grade (p = .0133), and positive lymph nodal status (p = .0002). Additionally, high RAI3 staining predicted shortened overall survival of EAC and ESCC patients (p = .0298 and p = .0227). RAI3 overexpression is associated with poor prognosis in esophageal cancers. We propose that RAI3 overexpression might play a biologically relevant role of RAI3 in esophageal cancers.

KW - Adenocarcinoma/mortality

KW - Adult

KW - Aged

KW - Biomarkers, Tumor/analysis

KW - Esophageal Neoplasms/mortality

KW - Esophageal Squamous Cell Carcinoma/mortality

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Receptors, G-Protein-Coupled/biosynthesis

U2 - 10.1016/j.yexmp.2019.01.013

DO - 10.1016/j.yexmp.2019.01.013

M3 - SCORING: Journal articles

C2 - 30707896

VL - 107

SP - 51

EP - 56

JO - EXP MOL PATHOL

JF - EXP MOL PATHOL

SN - 0014-4800

ER -