Research ExplorerScientific StaffHermann Clemens Altmeppen

Dipl. Hum.-Biol. Dr. rer. nat. ID: 32498

Hermann Clemens Altmeppen

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Phone: 040-7410-58750

Research Interests

My current research focusses on how proteolytic processing events on key proteins impact on neurodegenerative diseases such as rare and transmissible prion diseases or Alzheimer`s disease, the most frequent cause of dementia.

Research Interests

Fields of specific interest:

Neurodegeneration, Cell biology, Infectious diseases, Proteolytic processing

Publications

Disordered structure and flexible roles: using the prion protein N1 fragment for neuroprotective and regenerative therapy

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

Show Me Your Friends and I Tell You Who You Are: The Many Facets of Prion Protein in Stroke

Research output: SCORING: Contribution to journal › SCORING: Review articles › Research

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

The cellular prion protein and its derived fragments in human prion diseases and their role as potential biomarkers

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

Muskelin Coordinates PrP Lysosome versus Exosome Targeting and Impacts Prion Disease Progression

Research output: SCORING: Contribution to journal › SCORING: Journal articles › Research › peer-review

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activities

Research Grant of the "Werner Otto Stiftung"

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

Research Grant of the American “Creutzfeldt-Jakob Disease Foundation, Inc.”: for the project “Targeting the endogenous proteolytic processing of PrPC as a therapeutic strategy against prion diseases”

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

Admission to/Member of the Collaborative Research Center CRC877 (SFB877) “Proteolysis as a regulatory event in pathophysiology” (Kiel & Hamburg, 2nd Funding period) with the project A12 on “ADAM10-mediated shedding of the prion protein”

Activity: Other › Distinctions, awards, fellowships and visits - Other › Research

Young Scientists Research Grant of the Medical Faculty, University Medical Center Hamburg Eppendorf (UKE)

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

“Werner Otto Stipendium”

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

Leibniz Center Infection (LCI) Graduate School “Modell Systems for Infectious Diseases”: Doktorandenstipendium

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

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