Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice

Abstract

The uptake of glucose, non-esterified fatty acids, and triglycerides into brown adipose tissue is an important determinant of systemic energy metabolism, which can be studied by metabolic turnover studies using radioactive tracers in vivo. Here, we address the uptake of glucose and lipid tracers into metabolically active organs with a focus on thermogenically activated adipose tissues. Uptake by beige and brown adipocytes is highly dependent on conditions such as ambient temperature, but also varies between fasted compared to postprandial states. Accordingly, we provide methodological insights how to quantify glucose and lipid disposal under multiple physiological and environmental conditions.

Bibliografische Daten

OriginalspracheEnglisch
TitelBrown Adipose Tissue : Methods and Protocols
ERFORDERLICH bei Buchbeitrag: Seitenumfang12
ErscheinungsortNew York, NY
Herausgeber (Verlag)HUMANA PRESS INC
Erscheinungsdatum2022
Auflage1
Seiten107-118
ISBN (Print)978-1-0716-2086-1, 978-1-0716-2089-2
ISBN (elektronisch)978-1-0716-2087-8
DOIs
StatusVeröffentlicht - 2022

Anmerkungen des Dekanats

© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

PubMed 35167093