Light therapy improves diurnal blood pressure control in night shift workers via reduction of catecholamines: the EuRhythDia study

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Light therapy improves diurnal blood pressure control in night shift workers via reduction of catecholamines: the EuRhythDia study. / Hannemann, Juliane; Laing, Anika; Middleton, Benita; Cridland, Jonathan; Staels, Bart; Marx, Nikolaus; Grant, Peter J; Federici, Massimo; Stenberg, Tarja; Skene, Debra J; Böger, Rainer.

in: J HYPERTENS, Jahrgang 39, Nr. 8, 01.08.2021, S. 1678-1688.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsätzeForschungBegutachtung

Harvard

Hannemann, J, Laing, A, Middleton, B, Cridland, J, Staels, B, Marx, N, Grant, PJ, Federici, M, Stenberg, T, Skene, DJ & Böger, R 2021, 'Light therapy improves diurnal blood pressure control in night shift workers via reduction of catecholamines: the EuRhythDia study', J HYPERTENS, Jg. 39, Nr. 8, S. 1678-1688. https://doi.org/10.1097/HJH.0000000000002848

APA

Hannemann, J., Laing, A., Middleton, B., Cridland, J., Staels, B., Marx, N., Grant, P. J., Federici, M., Stenberg, T., Skene, D. J., & Böger, R. (2021). Light therapy improves diurnal blood pressure control in night shift workers via reduction of catecholamines: the EuRhythDia study. J HYPERTENS, 39(8), 1678-1688. https://doi.org/10.1097/HJH.0000000000002848

Vancouver

Bibtex

@article{8e6487115e544972a13f747081be5086,
title = "Light therapy improves diurnal blood pressure control in night shift workers via reduction of catecholamines: the EuRhythDia study",
abstract = "OBJECTIVES: Night shift work is associated with high rates of hypertension and cardiometabolic disease, which are linked to disrupted circadian rhythms. We hypothesized that timed light therapy might improve disrupted circadian rhythms and stabilize diurnal control of blood pressure and glucose in night shift workers.METHODS: We randomized 24 rotating night shift workers (mean age, 36 ± 13 years, 7 men) who had spent a median of 6 years on rotating night shifts (median, six night shifts per month) to 12 weeks of light therapy or no intervention and compared them with 12 daytime workers (37 ± 11 years, 6 men). We measured oral glucose tolerance (OGTT), 24-h blood pressure and arterial stiffness, and the circadian profiles of melatonin, cortisol, metanephrine and nor-metanephrine at baseline, after 12 weeks of intervention, and 12 weeks after the end of intervention.RESULTS: At baseline, fewer night shift workers showed dipper status as compared with daytime workers (29 vs. 58%; P < 0.001). After 12 weeks of light therapy, there was a highly significant increase in the proportion of dippers (to 58%; P < 0.0001). We also observed a significant decrease in serum glucose during OGTT in the light therapy group (-22%; P < 0.05) with no change in serum insulin. Whilst circadian profiles of melatonin and cortisol were unchanged, plasma metanephrine and nor-metanephrine levels were significantly reduced in the light therapy group (P < 0.01).CONCLUSION: Timed light therapy improves diurnal blood pressure control and glucose tolerance in rotating night shift workers. This effect is unrelated to melatonin and cortisol but is paralleled by reduced catecholamine levels.",
author = "Juliane Hannemann and Anika Laing and Benita Middleton and Jonathan Cridland and Bart Staels and Nikolaus Marx and Grant, {Peter J} and Massimo Federici and Tarja Stenberg and Skene, {Debra J} and Rainer B{\"o}ger",
note = "Copyright {\textcopyright} 2021 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2021",
month = aug,
day = "1",
doi = "10.1097/HJH.0000000000002848",
language = "English",
volume = "39",
pages = "1678--1688",
journal = "J HYPERTENS",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Light therapy improves diurnal blood pressure control in night shift workers via reduction of catecholamines: the EuRhythDia study

AU - Hannemann, Juliane

AU - Laing, Anika

AU - Middleton, Benita

AU - Cridland, Jonathan

AU - Staels, Bart

AU - Marx, Nikolaus

AU - Grant, Peter J

AU - Federici, Massimo

AU - Stenberg, Tarja

AU - Skene, Debra J

AU - Böger, Rainer

N1 - Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - OBJECTIVES: Night shift work is associated with high rates of hypertension and cardiometabolic disease, which are linked to disrupted circadian rhythms. We hypothesized that timed light therapy might improve disrupted circadian rhythms and stabilize diurnal control of blood pressure and glucose in night shift workers.METHODS: We randomized 24 rotating night shift workers (mean age, 36 ± 13 years, 7 men) who had spent a median of 6 years on rotating night shifts (median, six night shifts per month) to 12 weeks of light therapy or no intervention and compared them with 12 daytime workers (37 ± 11 years, 6 men). We measured oral glucose tolerance (OGTT), 24-h blood pressure and arterial stiffness, and the circadian profiles of melatonin, cortisol, metanephrine and nor-metanephrine at baseline, after 12 weeks of intervention, and 12 weeks after the end of intervention.RESULTS: At baseline, fewer night shift workers showed dipper status as compared with daytime workers (29 vs. 58%; P < 0.001). After 12 weeks of light therapy, there was a highly significant increase in the proportion of dippers (to 58%; P < 0.0001). We also observed a significant decrease in serum glucose during OGTT in the light therapy group (-22%; P < 0.05) with no change in serum insulin. Whilst circadian profiles of melatonin and cortisol were unchanged, plasma metanephrine and nor-metanephrine levels were significantly reduced in the light therapy group (P < 0.01).CONCLUSION: Timed light therapy improves diurnal blood pressure control and glucose tolerance in rotating night shift workers. This effect is unrelated to melatonin and cortisol but is paralleled by reduced catecholamine levels.

AB - OBJECTIVES: Night shift work is associated with high rates of hypertension and cardiometabolic disease, which are linked to disrupted circadian rhythms. We hypothesized that timed light therapy might improve disrupted circadian rhythms and stabilize diurnal control of blood pressure and glucose in night shift workers.METHODS: We randomized 24 rotating night shift workers (mean age, 36 ± 13 years, 7 men) who had spent a median of 6 years on rotating night shifts (median, six night shifts per month) to 12 weeks of light therapy or no intervention and compared them with 12 daytime workers (37 ± 11 years, 6 men). We measured oral glucose tolerance (OGTT), 24-h blood pressure and arterial stiffness, and the circadian profiles of melatonin, cortisol, metanephrine and nor-metanephrine at baseline, after 12 weeks of intervention, and 12 weeks after the end of intervention.RESULTS: At baseline, fewer night shift workers showed dipper status as compared with daytime workers (29 vs. 58%; P < 0.001). After 12 weeks of light therapy, there was a highly significant increase in the proportion of dippers (to 58%; P < 0.0001). We also observed a significant decrease in serum glucose during OGTT in the light therapy group (-22%; P < 0.05) with no change in serum insulin. Whilst circadian profiles of melatonin and cortisol were unchanged, plasma metanephrine and nor-metanephrine levels were significantly reduced in the light therapy group (P < 0.01).CONCLUSION: Timed light therapy improves diurnal blood pressure control and glucose tolerance in rotating night shift workers. This effect is unrelated to melatonin and cortisol but is paralleled by reduced catecholamine levels.

U2 - 10.1097/HJH.0000000000002848

DO - 10.1097/HJH.0000000000002848

M3 - SCORING: Journal articles

C2 - 33710166

VL - 39

SP - 1678

EP - 1688

JO - J HYPERTENS

JF - J HYPERTENS

SN - 0263-6352

IS - 8

ER -