GPER1 Signaling Initiates Migration of Female V-SVZ-Derived Cells

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GPER1 Signaling Initiates Migration of Female V-SVZ-Derived Cells. / Haumann, Iris; Sturm, Muriel Anne; Anstötz, Max; Rune, Gabriele M.

in: iScience, Jahrgang 23, Nr. 5, 22.05.2020, S. 101077.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsätzeForschungBegutachtung

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@article{63655dce0be24ce5b0c783269724f902,
title = "GPER1 Signaling Initiates Migration of Female V-SVZ-Derived Cells",
abstract = "In the rodent ventricular-subventricular zone (V-SVZ) neurons are generated throughout life. They migrate along the rostral migratory stream (RMS) into the olfactory bulb before their final differentiation into interneurons and integration into local circuits. Estrogen receptors (ERs) are steroid hormone receptors with important functions in neurogenesis and synaptic plasticity. In this study, we show that the ER GPER1 is expressed in subsets of cells within the V-SVZ of female animals and provide evidence for a potential local estrogen source from aromatase-positive astrocytes surrounding the RMS. Blocking of GPER1 in Matrigel cultures of female animals significantly impairs migration of V-SVZ-derived cells. This outgrowth is accompanied by regulation of phosphorylation of the actin-binding protein cofilin by GPER1 signaling including an involvement of the p21-Ras pathway. Our results point to a prominent role of GPER1 in the initiation of neuronal migration from the V-SVZ to the olfactory bulb.",
author = "Iris Haumann and Sturm, {Muriel Anne} and Max Anst{\"o}tz and Rune, {Gabriele M}",
note = "Copyright {\textcopyright} 2020 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = may,
day = "22",
doi = "10.1016/j.isci.2020.101077",
language = "English",
volume = "23",
pages = "101077",
number = "5",

}

RIS

TY - JOUR

T1 - GPER1 Signaling Initiates Migration of Female V-SVZ-Derived Cells

AU - Haumann, Iris

AU - Sturm, Muriel Anne

AU - Anstötz, Max

AU - Rune, Gabriele M

N1 - Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2020/5/22

Y1 - 2020/5/22

N2 - In the rodent ventricular-subventricular zone (V-SVZ) neurons are generated throughout life. They migrate along the rostral migratory stream (RMS) into the olfactory bulb before their final differentiation into interneurons and integration into local circuits. Estrogen receptors (ERs) are steroid hormone receptors with important functions in neurogenesis and synaptic plasticity. In this study, we show that the ER GPER1 is expressed in subsets of cells within the V-SVZ of female animals and provide evidence for a potential local estrogen source from aromatase-positive astrocytes surrounding the RMS. Blocking of GPER1 in Matrigel cultures of female animals significantly impairs migration of V-SVZ-derived cells. This outgrowth is accompanied by regulation of phosphorylation of the actin-binding protein cofilin by GPER1 signaling including an involvement of the p21-Ras pathway. Our results point to a prominent role of GPER1 in the initiation of neuronal migration from the V-SVZ to the olfactory bulb.

AB - In the rodent ventricular-subventricular zone (V-SVZ) neurons are generated throughout life. They migrate along the rostral migratory stream (RMS) into the olfactory bulb before their final differentiation into interneurons and integration into local circuits. Estrogen receptors (ERs) are steroid hormone receptors with important functions in neurogenesis and synaptic plasticity. In this study, we show that the ER GPER1 is expressed in subsets of cells within the V-SVZ of female animals and provide evidence for a potential local estrogen source from aromatase-positive astrocytes surrounding the RMS. Blocking of GPER1 in Matrigel cultures of female animals significantly impairs migration of V-SVZ-derived cells. This outgrowth is accompanied by regulation of phosphorylation of the actin-binding protein cofilin by GPER1 signaling including an involvement of the p21-Ras pathway. Our results point to a prominent role of GPER1 in the initiation of neuronal migration from the V-SVZ to the olfactory bulb.

U2 - 10.1016/j.isci.2020.101077

DO - 10.1016/j.isci.2020.101077

M3 - SCORING: Journal articles

C2 - 32361597

VL - 23

SP - 101077

IS - 5

ER -