Evaluation of Periodontal Space Widening in Patients with Antiresorptive Drug-related Osteonecrosis of the Jaws (ARONJ) on Panoramic Radiographs

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Evaluation of Periodontal Space Widening in Patients with Antiresorptive Drug-related Osteonecrosis of the Jaws (ARONJ) on Panoramic Radiographs. / Assaf, Alexandre T; Amberg, Vivien; Smeets, Ralf; Wikner, Johannes; Hanken, Henning; Semmusch, Jan; Ewald, Florian; Rashad, Ashkan; Friedrich, Reinhard E.

in: ANTICANCER RES, Jahrgang 38, Nr. 9, 09.2018, S. 5305-5314.

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@article{c05a0689fa1e4069a5af09703a2b67f1,
title = "Evaluation of Periodontal Space Widening in Patients with Antiresorptive Drug-related Osteonecrosis of the Jaws (ARONJ) on Panoramic Radiographs",
abstract = "BACKGROUND/AIM: The purpose of this study was to evaluate a potential widening of the periodontal space as an initial measurable imaging criterium on panoramic radiographs in patients with the diagnosis of antiresorptive drug related osteonecrosis of the jaw (ARONJ).PATIENTS AND METHODS: A retrospective analysis of panoramic radiographs of 16 patients (12 females and 4 males; mean age is 70.5 years, standard deviation is 14 years) was performed, over a period of 12 months with the diagnosis of ARONJ. Panoramic radiographs of 16 healthy patients (12 females and 4 males; mean age was 70.6 years, standard deviation was 13.8 years) without diagnosis of ARONJ served as controls. All images were taken with the same device and were evaluated by two experienced maxillofacial surgeons and one dentist.RESULTS: Compared to the control group, a mean widening of the periodontal space of 0.06 mm (confidence interval (CI)=0.05-0.17 mm) was found in the study group. However, this difference was not statistically significant.CONCLUSION: Although a very extensive and sophisticated interindividual comparison was performed to evaluate for slight changes of the periodontal space in patients with antiresorptive drug therapy, our results demonstrate that PDS widening is not a predictive parameter for ARONJ. Therefore, our results indicate that panoramic radiographs are not sufficient enough to allow assessment of stages and disease progress in ARONJ patients regarding to periodontal space widening.",
keywords = "Adult, Aged, Aged, 80 and over, Alveolar Process, Bisphosphonate-Associated Osteonecrosis of the Jaw, Bone Density Conservation Agents, Female, Humans, Male, Middle Aged, Observer Variation, Predictive Value of Tests, Radiography, Panoramic, Reproducibility of Results, Retrospective Studies, Severity of Illness Index, Journal Article",
author = "Assaf, {Alexandre T} and Vivien Amberg and Ralf Smeets and Johannes Wikner and Henning Hanken and Jan Semmusch and Florian Ewald and Ashkan Rashad and Friedrich, {Reinhard E}",
note = "Copyright{\textcopyright} 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.",
year = "2018",
month = sep,
doi = "10.21873/anticanres.12857",
language = "English",
volume = "38",
pages = "5305--5314",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "9",

}

RIS

TY - JOUR

T1 - Evaluation of Periodontal Space Widening in Patients with Antiresorptive Drug-related Osteonecrosis of the Jaws (ARONJ) on Panoramic Radiographs

AU - Assaf, Alexandre T

AU - Amberg, Vivien

AU - Smeets, Ralf

AU - Wikner, Johannes

AU - Hanken, Henning

AU - Semmusch, Jan

AU - Ewald, Florian

AU - Rashad, Ashkan

AU - Friedrich, Reinhard E

N1 - Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

PY - 2018/9

Y1 - 2018/9

N2 - BACKGROUND/AIM: The purpose of this study was to evaluate a potential widening of the periodontal space as an initial measurable imaging criterium on panoramic radiographs in patients with the diagnosis of antiresorptive drug related osteonecrosis of the jaw (ARONJ).PATIENTS AND METHODS: A retrospective analysis of panoramic radiographs of 16 patients (12 females and 4 males; mean age is 70.5 years, standard deviation is 14 years) was performed, over a period of 12 months with the diagnosis of ARONJ. Panoramic radiographs of 16 healthy patients (12 females and 4 males; mean age was 70.6 years, standard deviation was 13.8 years) without diagnosis of ARONJ served as controls. All images were taken with the same device and were evaluated by two experienced maxillofacial surgeons and one dentist.RESULTS: Compared to the control group, a mean widening of the periodontal space of 0.06 mm (confidence interval (CI)=0.05-0.17 mm) was found in the study group. However, this difference was not statistically significant.CONCLUSION: Although a very extensive and sophisticated interindividual comparison was performed to evaluate for slight changes of the periodontal space in patients with antiresorptive drug therapy, our results demonstrate that PDS widening is not a predictive parameter for ARONJ. Therefore, our results indicate that panoramic radiographs are not sufficient enough to allow assessment of stages and disease progress in ARONJ patients regarding to periodontal space widening.

AB - BACKGROUND/AIM: The purpose of this study was to evaluate a potential widening of the periodontal space as an initial measurable imaging criterium on panoramic radiographs in patients with the diagnosis of antiresorptive drug related osteonecrosis of the jaw (ARONJ).PATIENTS AND METHODS: A retrospective analysis of panoramic radiographs of 16 patients (12 females and 4 males; mean age is 70.5 years, standard deviation is 14 years) was performed, over a period of 12 months with the diagnosis of ARONJ. Panoramic radiographs of 16 healthy patients (12 females and 4 males; mean age was 70.6 years, standard deviation was 13.8 years) without diagnosis of ARONJ served as controls. All images were taken with the same device and were evaluated by two experienced maxillofacial surgeons and one dentist.RESULTS: Compared to the control group, a mean widening of the periodontal space of 0.06 mm (confidence interval (CI)=0.05-0.17 mm) was found in the study group. However, this difference was not statistically significant.CONCLUSION: Although a very extensive and sophisticated interindividual comparison was performed to evaluate for slight changes of the periodontal space in patients with antiresorptive drug therapy, our results demonstrate that PDS widening is not a predictive parameter for ARONJ. Therefore, our results indicate that panoramic radiographs are not sufficient enough to allow assessment of stages and disease progress in ARONJ patients regarding to periodontal space widening.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alveolar Process

KW - Bisphosphonate-Associated Osteonecrosis of the Jaw

KW - Bone Density Conservation Agents

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Observer Variation

KW - Predictive Value of Tests

KW - Radiography, Panoramic

KW - Reproducibility of Results

KW - Retrospective Studies

KW - Severity of Illness Index

KW - Journal Article

U2 - 10.21873/anticanres.12857

DO - 10.21873/anticanres.12857

M3 - SCORING: Journal articles

C2 - 30194182

VL - 38

SP - 5305

EP - 5314

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 9

ER -