Epithelial-mesenchymal Transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

Abstract

Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we summarize the knowledge with regard to the small potentially druggable molecules capable of modulating EMT for cancer therapy.

Bibliografische Daten

OriginalspracheEnglisch
ISSN1476-4598
DOIs
StatusVeröffentlicht - 01.01.2013
PubMed 24053443