C-Reactive Protein in the Prediction of Localization of Gastrointestinal Perforation

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C-Reactive Protein in the Prediction of Localization of Gastrointestinal Perforation. / Grupp, Katharina; Grotelüschen, Rainer; Uzunoglu, Faik Güntac; Hofmann, Bianca; König, Alexandra; Perez, Daniel; Bockhorn, Maximillian; Izbicki, Jakob Robert; Bachmann, Kai.

in: EUR SURG RES, Jahrgang 60, Nr. 5-6, 2019, S. 179-185.

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@article{a8bd95446d4047b8b6d8ae747a9209ab,
title = "C-Reactive Protein in the Prediction of Localization of Gastrointestinal Perforation",
abstract = "AIM: Information regarding the localization of the anatomic site of gastrointestinal (GI) tract perforation is essential for the following surgical procedure. The purpose of this study was to evaluate the significance of C-reactive protein (CRP) and other circulating markers for the prediction of the localization of intra-abdominal hollow organ perforation.METHODS: Measurements of serum markers were analyzed in 423 patients with GI tract perforations, who were divided according to the intraoperative diagnosis into colorectal and upper GI tract perforation groups.RESULTS: Levels of CRP were higher in patients with colorectal perforations than in upper GI tract perforations (p < 0.001). Moreover, high levels of CRP were associated with increased mortality of patients with hollow organ perforations (p = 0.009), which was largely driven by the subset of patients with perforations of the upper GI tract (p = 0.001).CONCLUSION: Increased CRP levels predict worse clinical outcome in patients with intra-abdominal hollow organ perforations and are associated with perforations in the colorectal tract. Thus, CRP might be a useful marker for preoperative risk stratification and prediction of the localization of the perforation site.",
author = "Katharina Grupp and Rainer Grotel{\"u}schen and Uzunoglu, {Faik G{\"u}ntac} and Bianca Hofmann and Alexandra K{\"o}nig and Daniel Perez and Maximillian Bockhorn and Izbicki, {Jakob Robert} and Kai Bachmann",
note = "{\textcopyright} 2019 S. Karger AG, Basel.",
year = "2019",
doi = "10.1159/000501806",
language = "English",
volume = "60",
pages = "179--185",
number = "5-6",

}

RIS

TY - JOUR

T1 - C-Reactive Protein in the Prediction of Localization of Gastrointestinal Perforation

AU - Grupp, Katharina

AU - Grotelüschen, Rainer

AU - Uzunoglu, Faik Güntac

AU - Hofmann, Bianca

AU - König, Alexandra

AU - Perez, Daniel

AU - Bockhorn, Maximillian

AU - Izbicki, Jakob Robert

AU - Bachmann, Kai

N1 - © 2019 S. Karger AG, Basel.

PY - 2019

Y1 - 2019

N2 - AIM: Information regarding the localization of the anatomic site of gastrointestinal (GI) tract perforation is essential for the following surgical procedure. The purpose of this study was to evaluate the significance of C-reactive protein (CRP) and other circulating markers for the prediction of the localization of intra-abdominal hollow organ perforation.METHODS: Measurements of serum markers were analyzed in 423 patients with GI tract perforations, who were divided according to the intraoperative diagnosis into colorectal and upper GI tract perforation groups.RESULTS: Levels of CRP were higher in patients with colorectal perforations than in upper GI tract perforations (p < 0.001). Moreover, high levels of CRP were associated with increased mortality of patients with hollow organ perforations (p = 0.009), which was largely driven by the subset of patients with perforations of the upper GI tract (p = 0.001).CONCLUSION: Increased CRP levels predict worse clinical outcome in patients with intra-abdominal hollow organ perforations and are associated with perforations in the colorectal tract. Thus, CRP might be a useful marker for preoperative risk stratification and prediction of the localization of the perforation site.

AB - AIM: Information regarding the localization of the anatomic site of gastrointestinal (GI) tract perforation is essential for the following surgical procedure. The purpose of this study was to evaluate the significance of C-reactive protein (CRP) and other circulating markers for the prediction of the localization of intra-abdominal hollow organ perforation.METHODS: Measurements of serum markers were analyzed in 423 patients with GI tract perforations, who were divided according to the intraoperative diagnosis into colorectal and upper GI tract perforation groups.RESULTS: Levels of CRP were higher in patients with colorectal perforations than in upper GI tract perforations (p < 0.001). Moreover, high levels of CRP were associated with increased mortality of patients with hollow organ perforations (p = 0.009), which was largely driven by the subset of patients with perforations of the upper GI tract (p = 0.001).CONCLUSION: Increased CRP levels predict worse clinical outcome in patients with intra-abdominal hollow organ perforations and are associated with perforations in the colorectal tract. Thus, CRP might be a useful marker for preoperative risk stratification and prediction of the localization of the perforation site.

U2 - 10.1159/000501806

DO - 10.1159/000501806

M3 - SCORING: Journal articles

C2 - 31743923

VL - 60

SP - 179

EP - 185

IS - 5-6

ER -