B cell analysis in SARS‐CoV‐2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID‐19

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B cell analysis in SARS‐CoV‐2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID‐19. / Wildner, Nils H; Ahmadi, Parimah; Schulte, Sophia; Brauneck, Franziska; Kohsar, Matin; Lütgehetmann, Marc; Beisel, Claudia; Addo, Marylyn Martina; Haag, Friedrich; Schulze zur Wiesch, Julian.

in: J LEUKOCYTE BIOL, Jahrgang 109, Nr. 1, 01.2021, S. 77-90.

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@article{ae75f9ade5fe4616b43dcded829ea47a,
title = "B cell analysis in SARS‐CoV‐2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID‐19",
abstract = "B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibod-ies, but also as APCs and mediators of inflammation. In this study, we used 16-color flow cytom-etry analysis to investigate the frequency, differentiation, and activation status of peripheral Bcells of patientswith SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared withthe healthy individuals. As a main result, we observed an increase of the frequency of (CD27–,CD21–) atypical memoryB cells and (CD19+,CD27+,CD38+) plasmablasts inmalaria and COVID-19 patients. Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereasCD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared withthe bulk B cell population. In particular, there was a more pronounced loss of CD73+B cells inmalaria. The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, andLDH of COVID-19 patients. In the longitudinal course of COVID-19, a rapid normalization of thefrequency of atypical memory B cells was observed. The role and function of plasmablasts andatypical memory B cells in COVID-19 and other acute infections remain to be further investigated.The role of B cells as either “driver or passenger” of hyperinflammation during COVID-19 needsto be clarified",
author = "Wildner, {Nils H} and Parimah Ahmadi and Sophia Schulte and Franziska Brauneck and Matin Kohsar and Marc L{\"u}tgehetmann and Claudia Beisel and Addo, {Marylyn Martina} and Friedrich Haag and {Schulze zur Wiesch}, Julian",
year = "2021",
month = jan,
doi = "10.1002/jlb.5cova0620-370rr",
language = "English",
volume = "109",
pages = "77--90",
journal = "J LEUKOCYTE BIOL",
issn = "0741-5400",
publisher = "FASEB",
number = "1",

}

RIS

TY - JOUR

T1 - B cell analysis in SARS‐CoV‐2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID‐19

AU - Wildner, Nils H

AU - Ahmadi, Parimah

AU - Schulte, Sophia

AU - Brauneck, Franziska

AU - Kohsar, Matin

AU - Lütgehetmann, Marc

AU - Beisel, Claudia

AU - Addo, Marylyn Martina

AU - Haag, Friedrich

AU - Schulze zur Wiesch, Julian

PY - 2021/1

Y1 - 2021/1

N2 - B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibod-ies, but also as APCs and mediators of inflammation. In this study, we used 16-color flow cytom-etry analysis to investigate the frequency, differentiation, and activation status of peripheral Bcells of patientswith SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared withthe healthy individuals. As a main result, we observed an increase of the frequency of (CD27–,CD21–) atypical memoryB cells and (CD19+,CD27+,CD38+) plasmablasts inmalaria and COVID-19 patients. Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereasCD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared withthe bulk B cell population. In particular, there was a more pronounced loss of CD73+B cells inmalaria. The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, andLDH of COVID-19 patients. In the longitudinal course of COVID-19, a rapid normalization of thefrequency of atypical memory B cells was observed. The role and function of plasmablasts andatypical memory B cells in COVID-19 and other acute infections remain to be further investigated.The role of B cells as either “driver or passenger” of hyperinflammation during COVID-19 needsto be clarified

AB - B cells play a central role in antiviral and antiparasitic immunity, not only as producers of antibod-ies, but also as APCs and mediators of inflammation. In this study, we used 16-color flow cytom-etry analysis to investigate the frequency, differentiation, and activation status of peripheral Bcells of patientswith SARS-CoV-2 infection or acute Plasmodium falciparum malaria compared withthe healthy individuals. As a main result, we observed an increase of the frequency of (CD27–,CD21–) atypical memoryB cells and (CD19+,CD27+,CD38+) plasmablasts inmalaria and COVID-19 patients. Additionally, CD86, PD-1, CXCR3, and CD39 expression was up-regulated, whereasCD73 was down-regulated on plasmablasts of COVID-19 and malaria patients compared withthe bulk B cell population. In particular, there was a more pronounced loss of CD73+B cells inmalaria. The frequency of plasmablasts positively correlated with serum levels of CRP, IL-6, andLDH of COVID-19 patients. In the longitudinal course of COVID-19, a rapid normalization of thefrequency of atypical memory B cells was observed. The role and function of plasmablasts andatypical memory B cells in COVID-19 and other acute infections remain to be further investigated.The role of B cells as either “driver or passenger” of hyperinflammation during COVID-19 needsto be clarified

UR - http://dx.doi.org/10.1002/jlb.5cova0620-370rr

U2 - 10.1002/jlb.5cova0620-370rr

DO - 10.1002/jlb.5cova0620-370rr

M3 - SCORING: Journal articles

VL - 109

SP - 77

EP - 90

JO - J LEUKOCYTE BIOL

JF - J LEUKOCYTE BIOL

SN - 0741-5400

IS - 1

ER -