Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium

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Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium. / Aust, Stefanie; Auer, Katharina; Bachmayr-Heyda, Anna; Denkert, Carsten; Sehouli, Jalid; Braicu, Ioana; Mahner, Sven; Lambrechts, Sandrina; Vergote, Ignace; Grimm, Christoph; Horvat, Reinhard; Castillo-Tong, Dan Cacsire; Zeillinger, Robert; Pils, Dietmar.

in: MOL CANCER, Jahrgang 13, 01.01.2014, S. 67.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsätzeForschungBegutachtung

Harvard

Aust, S, Auer, K, Bachmayr-Heyda, A, Denkert, C, Sehouli, J, Braicu, I, Mahner, S, Lambrechts, S, Vergote, I, Grimm, C, Horvat, R, Castillo-Tong, DC, Zeillinger, R & Pils, D 2014, 'Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium', MOL CANCER, Jg. 13, S. 67. https://doi.org/10.1186/1476-4598-13-67

APA

Aust, S., Auer, K., Bachmayr-Heyda, A., Denkert, C., Sehouli, J., Braicu, I., Mahner, S., Lambrechts, S., Vergote, I., Grimm, C., Horvat, R., Castillo-Tong, D. C., Zeillinger, R., & Pils, D. (2014). Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium. MOL CANCER, 13, 67. https://doi.org/10.1186/1476-4598-13-67

Vancouver

Aust S, Auer K, Bachmayr-Heyda A, Denkert C, Sehouli J, Braicu I et al. Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium. MOL CANCER. 2014 Jan 1;13:67. https://doi.org/10.1186/1476-4598-13-67

Bibtex

@article{f7f3dcd2cdc64b72ba2fd06b9943a2dc,
title = "Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium",
abstract = "BACKGROUND: Focal adhesion kinase (FAK) autophosphorylation seems to be a potential therapeutic target but little is known about the role and prognostic value of FAK and pFAK in epithelial ovarian cancer (EOC). Recently, we validated a gene signature classifying EOC patients into two subclasses and revealing genes of the focal adhesion pathway as significantly deregulated.METHODS: FAK expression and pFAK-Y397 abundance were elucidated by immunohistochemistry and microarray analysis in 179 serous EOC patients. In particular the prognostic value of phosphorylated FAK (pFAK-Y397) and FAK in advanced stage EOC was investigated.RESULTS: Multiple Cox-regression analysis showed that high pFAK abundance was associated with improved overall survival (HR 0.54; p = 0.034). FAK was positive in a total of 92.2% (n = 165) and high pFAK abundance was found in 36.9% (n = 66). High pFAK abundance (36.9% ; n = 66) was associated with either nodal positivity and/or distant metastasis (p = 0.030). Whole genome gene expression data revealed a connection of the FAK-pFAK-Y397 axis and the mTOR-S6K1 pathway, shown to play a major role in carcinogenesis.CONCLUSION: The role of pFAK-Y397 remains controversial: although high pFAK-Y397 abundance is associated with distant and lymph node metastases, it is independently associated with improved overall survival.",
author = "Stefanie Aust and Katharina Auer and Anna Bachmayr-Heyda and Carsten Denkert and Jalid Sehouli and Ioana Braicu and Sven Mahner and Sandrina Lambrechts and Ignace Vergote and Christoph Grimm and Reinhard Horvat and Castillo-Tong, {Dan Cacsire} and Robert Zeillinger and Dietmar Pils",
year = "2014",
month = jan,
day = "1",
doi = "10.1186/1476-4598-13-67",
language = "English",
volume = "13",
pages = "67",
journal = "MOL CANCER",
issn = "1476-4598",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Ambivalent role of pFAK-Y397 in serous ovarian cancer-a study of the OVCAD consortium

AU - Aust, Stefanie

AU - Auer, Katharina

AU - Bachmayr-Heyda, Anna

AU - Denkert, Carsten

AU - Sehouli, Jalid

AU - Braicu, Ioana

AU - Mahner, Sven

AU - Lambrechts, Sandrina

AU - Vergote, Ignace

AU - Grimm, Christoph

AU - Horvat, Reinhard

AU - Castillo-Tong, Dan Cacsire

AU - Zeillinger, Robert

AU - Pils, Dietmar

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND: Focal adhesion kinase (FAK) autophosphorylation seems to be a potential therapeutic target but little is known about the role and prognostic value of FAK and pFAK in epithelial ovarian cancer (EOC). Recently, we validated a gene signature classifying EOC patients into two subclasses and revealing genes of the focal adhesion pathway as significantly deregulated.METHODS: FAK expression and pFAK-Y397 abundance were elucidated by immunohistochemistry and microarray analysis in 179 serous EOC patients. In particular the prognostic value of phosphorylated FAK (pFAK-Y397) and FAK in advanced stage EOC was investigated.RESULTS: Multiple Cox-regression analysis showed that high pFAK abundance was associated with improved overall survival (HR 0.54; p = 0.034). FAK was positive in a total of 92.2% (n = 165) and high pFAK abundance was found in 36.9% (n = 66). High pFAK abundance (36.9% ; n = 66) was associated with either nodal positivity and/or distant metastasis (p = 0.030). Whole genome gene expression data revealed a connection of the FAK-pFAK-Y397 axis and the mTOR-S6K1 pathway, shown to play a major role in carcinogenesis.CONCLUSION: The role of pFAK-Y397 remains controversial: although high pFAK-Y397 abundance is associated with distant and lymph node metastases, it is independently associated with improved overall survival.

AB - BACKGROUND: Focal adhesion kinase (FAK) autophosphorylation seems to be a potential therapeutic target but little is known about the role and prognostic value of FAK and pFAK in epithelial ovarian cancer (EOC). Recently, we validated a gene signature classifying EOC patients into two subclasses and revealing genes of the focal adhesion pathway as significantly deregulated.METHODS: FAK expression and pFAK-Y397 abundance were elucidated by immunohistochemistry and microarray analysis in 179 serous EOC patients. In particular the prognostic value of phosphorylated FAK (pFAK-Y397) and FAK in advanced stage EOC was investigated.RESULTS: Multiple Cox-regression analysis showed that high pFAK abundance was associated with improved overall survival (HR 0.54; p = 0.034). FAK was positive in a total of 92.2% (n = 165) and high pFAK abundance was found in 36.9% (n = 66). High pFAK abundance (36.9% ; n = 66) was associated with either nodal positivity and/or distant metastasis (p = 0.030). Whole genome gene expression data revealed a connection of the FAK-pFAK-Y397 axis and the mTOR-S6K1 pathway, shown to play a major role in carcinogenesis.CONCLUSION: The role of pFAK-Y397 remains controversial: although high pFAK-Y397 abundance is associated with distant and lymph node metastases, it is independently associated with improved overall survival.

U2 - 10.1186/1476-4598-13-67

DO - 10.1186/1476-4598-13-67

M3 - SCORING: Journal articles

C2 - 24655477

VL - 13

SP - 67

JO - MOL CANCER

JF - MOL CANCER

SN - 1476-4598

ER -