Aberrant expression of Sec61α in esophageal cancers

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Aberrant expression of Sec61α in esophageal cancers. / Bachmann, Kai; Bockhorn, Maximillian; Mann, Oliver; Gebauer, Florian; Blessmann, Marco; Izbicki, Jakob Robert; Grupp, Katharina.

in: J CANCER RES CLIN, Jahrgang 145, Nr. 8, 08.2019, S. 2039-2044.

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@article{9b93564d731047d8bd98f71ee546264c,
title = "Aberrant expression of Sec61α in esophageal cancers",
abstract = "INTRODUCTION: The heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis and prognosis of patients.MATERIALS AND METHODS: Here, we analysed the role of Sec61α in esophageal cancer, and we analysed Sec61α staining on a tissue microarray containing more than 600 esophageal cancer specimens by immunohistochemistry.RESULTS: Sec61α staining was always strong in benign esophagus, but was only found in 5% of interpretable esophageal adenocarcinomas (EACs) and 14.5% of squamous cell carcinomas (ESCCs). Reduced Sec61α staining was not strongly linked to tumor phenotype in both subgroups of esophageal cancers and was unrelated to clinical outcome of patients (EACs: p = 0.8051 and ESCCs: p = 0.2751).CONCLUSIONS: Thus, Sec61α measurement has not an additional prognostic benefit for the patients.",
keywords = "Adenocarcinoma/diagnosis, Adult, Aged, Aged, 80 and over, Esophageal Neoplasms/diagnosis, Esophageal Squamous Cell Carcinoma/diagnosis, Female, Humans, Immunohistochemistry, Male, Middle Aged, Predictive Value of Tests, Prognosis, SEC Translocation Channels/metabolism, Tissue Array Analysis",
author = "Kai Bachmann and Maximillian Bockhorn and Oliver Mann and Florian Gebauer and Marco Blessmann and Izbicki, {Jakob Robert} and Katharina Grupp",
year = "2019",
month = aug,
doi = "10.1007/s00432-019-02955-7",
language = "English",
volume = "145",
pages = "2039--2044",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Aberrant expression of Sec61α in esophageal cancers

AU - Bachmann, Kai

AU - Bockhorn, Maximillian

AU - Mann, Oliver

AU - Gebauer, Florian

AU - Blessmann, Marco

AU - Izbicki, Jakob Robert

AU - Grupp, Katharina

PY - 2019/8

Y1 - 2019/8

N2 - INTRODUCTION: The heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis and prognosis of patients.MATERIALS AND METHODS: Here, we analysed the role of Sec61α in esophageal cancer, and we analysed Sec61α staining on a tissue microarray containing more than 600 esophageal cancer specimens by immunohistochemistry.RESULTS: Sec61α staining was always strong in benign esophagus, but was only found in 5% of interpretable esophageal adenocarcinomas (EACs) and 14.5% of squamous cell carcinomas (ESCCs). Reduced Sec61α staining was not strongly linked to tumor phenotype in both subgroups of esophageal cancers and was unrelated to clinical outcome of patients (EACs: p = 0.8051 and ESCCs: p = 0.2751).CONCLUSIONS: Thus, Sec61α measurement has not an additional prognostic benefit for the patients.

AB - INTRODUCTION: The heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis and prognosis of patients.MATERIALS AND METHODS: Here, we analysed the role of Sec61α in esophageal cancer, and we analysed Sec61α staining on a tissue microarray containing more than 600 esophageal cancer specimens by immunohistochemistry.RESULTS: Sec61α staining was always strong in benign esophagus, but was only found in 5% of interpretable esophageal adenocarcinomas (EACs) and 14.5% of squamous cell carcinomas (ESCCs). Reduced Sec61α staining was not strongly linked to tumor phenotype in both subgroups of esophageal cancers and was unrelated to clinical outcome of patients (EACs: p = 0.8051 and ESCCs: p = 0.2751).CONCLUSIONS: Thus, Sec61α measurement has not an additional prognostic benefit for the patients.

KW - Adenocarcinoma/diagnosis

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Esophageal Neoplasms/diagnosis

KW - Esophageal Squamous Cell Carcinoma/diagnosis

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prognosis

KW - SEC Translocation Channels/metabolism

KW - Tissue Array Analysis

U2 - 10.1007/s00432-019-02955-7

DO - 10.1007/s00432-019-02955-7

M3 - SCORING: Journal articles

C2 - 31197453

VL - 145

SP - 2039

EP - 2044

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 8

ER -